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What Happens When A Drug Works For Only One Person?

Klint Finley

From Nature:

By all rights, Gerald Batist’s patient should have died nine years ago. Her pancreatic cancer failed to flinch in the face of the standard arsenal — surgery, radiation, chemotherapy — and Batist, an oncologist at McGill University in Montreal, Canada, estimated that she had one year to live. With treatment options dwindling, he enrolled her in a clinical trial of a hot new class of drugs called farnesyltransferase inhibitors. Animal tests had suggested that the drugs had the potential to defeat some of the deadliest cancers, and pharmaceutical firms were racing to be the first to bring such compounds to market.

But the drugs flopped in clinical trials. Companies abandoned the inhibitors — one of the biggest heartbreaks in cancer research over the past decade. For Batist’s patient, however, the drugs were anything but disappointing. Her tumours were resolved; now, a decade later, she remains cancer free. And Batist hopes that he may soon find out why.

The US National Cancer Institute (NCI) in Bethesda, Maryland, is recruiting stories, tissue samples and clinical data from up to 200 such ‘exceptional responders’ to learn why these patients benefited from drugs that failed most others. The effort is part of a larger push among cancer researchers to focus on single-subject, or ‘n-of-1’, studies that could offer new insights into the disease. The tactic initially met with resistance, says Charles Sawyers, a cancer researcher at the Memorial Sloan-Kettering Cancer Center in New York and an advocate of the approach. “It’s in vogue to talk about your n-of-1 study now,” he says. “But when I was in medical school this was called an anecdote — and it was a bad word.”

Full Story: Nature: Cancer researchers revisit ‘failed’ clinical trials

(via Boing Boing)

Drugs Giants Used Communist East Germany For ‘Illegal’ Trials

Klint Finley

The Independent reports:

Leading Western pharmaceutical companies paid millions of pounds to former Communist East Germany to use more that 50,000 patients in state-run hospitals as unwitting guinea pigs for drug tests in which several people died, it was revealed today.

An investigation by the German magazine Der Spiegel said international conglomerates such as Bayer, Hoechst, Roche, Schering and Sandoz carried out more than 600 tests on patients, mostly without their knowledge, at hospitals and clinics in the former Communist state.

Full Story: The Independent: Drugs giants used Communist East Germany for ‘illegal’ trials

Mocking Hipsters In The Service Of Capital

Klint Finley

Anthony Galluzzo writes:

Even as the New York Times and its ilk now use hipster-bashing to delegitimize the new political awareness among the same un- and underemployed twenty- and thirty-somethings — previously taken to task for their avoidance of politics — the same bashers employ this all-purpose dummy to ventriloquize their own refined and slightly ridiculous consumption habits.

And while Rupert Murdoch’s reactionary gazetteers at least acknowledge the ongoing, and (in the case of 13 Thames Street) partly political character of the evictions in which they delight, the enlightened New York Times will always opt for the “fucking hipster” show — the 21st century bourgeois liberal’s preferred flavor of minstrelsy — over any ‘hard times’ depiction of downward mobility among artists, anarchists and other riffraff.

That, after all, could depress today’s gentrifiers or tomorrow’s property values.

Full Story: Jacobin: Mocking hipsters in the service of capital

Did Aleister Crowley Communicate With Grey Aliens?
Well maybe, but he never seemed to have thought so:

The idea that Crowley believed Aiwass and Lam to be the same entity, or that either were extraterrestrials from Sirius, is only the speculation of Kenneth Grant and those who have based their research on source material written by Grant. Additionally, very little can be said about the inspiration for the Lam portrait or what Aleister Crowley thought about it. […]
At least to the present author, this description of a kingly, tall, dark man in his thirties does not fit the Lam drawing. More importantly in relation to the subject of this post, the description does not match up at all with that of a “grey alien,” which many people relate to Lam.
The next important piece of information to take from Crowley’s depiction of Aiwass is that he never actually saw Aiwass at all. He only heard the voice of Aiwass from over his left shoulder, and from the furthest corner of the room. Not once did he actually look at Aiwass. His physical descriptions are only impressions.
So here we have a character description based only on non-visual impressions, and which doesn’t seem to correspond with the pictured Lam or grey aliens at all. This is the only known written description of Aiwass by Aleister Crowley.
Crowley himself never wrote much of anything at all about Lam, where the figure came from, or his ideas/thoughts about the subject in the drawing. What he did write was limited to a short, two sentence commentary in The Voice Of The Silence, which will be discussed later in this article.

Full Story: Blasted Tower: misconceptions about aleister crowley, lam, aiwass and alien contact
(via Brainsturbator)
See also: A Media History of Gray Aliens
An illustration of HG Wells’ tale of human evolution, “The Man of the Year Million,” is one of the oldest depictions of the “big headed genius” trope.
The concept is based on Lamarckian evolution, specifically the idea that body parts we use frequently will grow larger but parts we use less frequently will atrophy. Wells took this to the logical extreme, postulating (with tongue in cheek) that we would eventually grow gigantic brains and hands but tiny legs and torsos.

Did Aleister Crowley Communicate With Grey Aliens?

Well maybe, but he never seemed to have thought so:

The idea that Crowley believed Aiwass and Lam to be the same entity, or that either were extraterrestrials from Sirius, is only the speculation of Kenneth Grant and those who have based their research on source material written by Grant. Additionally, very little can be said about the inspiration for the Lam portrait or what Aleister Crowley thought about it. […]

At least to the present author, this description of a kingly, tall, dark man in his thirties does not fit the Lam drawing. More importantly in relation to the subject of this post, the description does not match up at all with that of a “grey alien,” which many people relate to Lam.

The next important piece of information to take from Crowley’s depiction of Aiwass is that he never actually saw Aiwass at all. He only heard the voice of Aiwass from over his left shoulder, and from the furthest corner of the room. Not once did he actually look at Aiwass. His physical descriptions are only impressions.

So here we have a character description based only on non-visual impressions, and which doesn’t seem to correspond with the pictured Lam or grey aliens at all. This is the only known written description of Aiwass by Aleister Crowley.

Crowley himself never wrote much of anything at all about Lam, where the figure came from, or his ideas/thoughts about the subject in the drawing. What he did write was limited to a short, two sentence commentary in The Voice Of The Silence, which will be discussed later in this article.

Full Story: Blasted Tower: misconceptions about aleister crowley, lam, aiwass and alien contact

(via Brainsturbator)

See also: A Media History of Gray Aliens

An illustration of HG Wells’ tale of human evolution, “The Man of the Year Million,” is one of the oldest depictions of the “big headed genius” trope.

The concept is based on Lamarckian evolution, specifically the idea that body parts we use frequently will grow larger but parts we use less frequently will atrophy. Wells took this to the logical extreme, postulating (with tongue in cheek) that we would eventually grow gigantic brains and hands but tiny legs and torsos.

Eco-Friendly Burials: Human Composting

Klint Finley

About 2.5 million people die every year in the U.S. alone. Disposing of human remains creates a serious ecological challenge. Traditional burials involve treating a body with formaldehyde and other chemicals then burying it in a wooden casket where it takes years to decompose. Cremation burns a lot of fossil fuel.

One possible alternative: a process is called promession, invented Swedish biologist Susanne Wiigh-Mäsak.

Mother Nature Network explains:

The breakthrough process takes only about six to 12 months to transform a dead body into high-nutrient compost. Here’s how it works: A corpse is first frozen to -18°C (0°F) and then submerged in liquid nitrogen. Then the frozen, brittle corpse is gently bombarded with sound waves, which break it down into a fine white powder. That powder is then sent through a vacuum chamber that evaporates all the water.

Since water makes up about 70 percent of an adult human body, the mass of the powdery corpse becomes greatly decreased. Also, if the powder is kept dry, it will not decompose. This erases the need for a speedy burial or funeral service, and it preserves the corpse without the need for any unnatural chemicals like embalming fluids.

When it does come time for a burial, the powder can then be placed in a box of biodegradable material like corn starch and buried in a shallow grave. The mixture will create nutritious, fertile soil, perfect for planting a tree, bush or garden, depending on the desires of the next of kin.

Full Story: Mother Nature Network: Green burial: How to turn a human body into compost

The Local has more on the company, and of course you can check out the official site.

(Thanks Beef!)

Big Dada, IRL Fetish And More On Mindful Cyborgs Episode 2

Mindful Cyborgs: Contemplative living in the age of quantification, augmentation and acceleration.

Hosts: Chris Dancy and Klint Finley.

Listen or download on Soundcloud and iTunes.

Follow: TwitterFacebookGoogle+Pinterest.

Transcript, show notes and more here.

Tunguska Event Meteorite Fragments Finally Unearthed

Klint Finley

Tunguska rocks

MIT Technology Review reports:

The Tunguska impact event is one of the great mysteries of modern history. The basic facts are well known. On 30 June 1908, a vast and powerful explosion engulfed an isolated region of Siberia near the Podkamennaya Tunguska River. […]

That changes today with the extraordinary announcement by Andrei Zlobin from the Russian Academy of Sciences that he has found three rocks from the Tunguska region with the telltale characteristics of meteorites. If he is right, these rocks could finally help solve once and for all what kind of object struck Earth all those years ago.

Full Story: MIT Technology Review: First Tunguska Meteorite Fragments Discovered

The catch: Zlobin collected the samples in 1988, and waited 20 years to analyze them, casting some uncertainty on his research.

Before Arpanet, The Secret Origins Of E-Mail
Colin Berkshire writes:

The invention of email is widely credited to be Ray Tomlinson (http://en.wikipedia.org/wiki/Ray_Tomlinson) in 1971. In one especially oddball webpage, VA Shiva Ayyadurai claims to have actually invented email in 1978. (http://www.inventorofemail.com). Mr. Ayyadurai mostly substantiates his claim by playing games with the definition of what email is, basically arguing that email didn’t exist until his particular program was written, and that nothing beforehand actually amounted to what he defines as being email. I won’t play those games with you here. […]
And, the #1 ESS ADF was in full production service February 3, 1969…almost five years before Ray Tomlinson sent the first email message and well before ARPANet even existed. To clarify, that was full commercial service…not a research laboratory.
When the #1 ESS ADF system was cut into service in 1969, it was of a truly massive scale for the time. 1,250 terminals located in 720 locations across the country were connected. These were used by Western Electric and AT&T Long Lines to send administrative messages, traffic orders, commercial service orders, payroll, plant service results, and budgeting reports. There was no other system, including universities, with such widespread use.

Full Story: Cloudave: The Origin of Email
The system is described in the Bell System Technical Journal in 1970, and is also mentioned by Jim Haynes in an essay on Teletype Corporation.

Before Arpanet, The Secret Origins Of E-Mail

Colin Berkshire writes:

The invention of email is widely credited to be Ray Tomlinson (http://en.wikipedia.org/wiki/Ray_Tomlinson) in 1971. In one especially oddball webpage, VA Shiva Ayyadurai claims to have actually invented email in 1978. (http://www.inventorofemail.com). Mr. Ayyadurai mostly substantiates his claim by playing games with the definition of what email is, basically arguing that email didn’t exist until his particular program was written, and that nothing beforehand actually amounted to what he defines as being email. I won’t play those games with you here. […]

And, the #1 ESS ADF was in full production service February 3, 1969…almost five years before Ray Tomlinson sent the first email message and well before ARPANet even existed. To clarify, that was full commercial service…not a research laboratory.

When the #1 ESS ADF system was cut into service in 1969, it was of a truly massive scale for the time. 1,250 terminals located in 720 locations across the country were connected. These were used by Western Electric and AT&T Long Lines to send administrative messages, traffic orders, commercial service orders, payroll, plant service results, and budgeting reports. There was no other system, including universities, with such widespread use.

Full Story: Cloudave: The Origin of Email

The system is described in the Bell System Technical Journal in 1970, and is also mentioned by Jim Haynes in an essay on Teletype Corporation.

Cyberculture History: The Origin Of E-Mail

Klint Finley

No. 1 ESS ADF

Colin Berkshire writes:

The invention of email is widely credited to be Ray Tomlinson (http://en.wikipedia.org/wiki/Ray_Tomlinson) in 1971. In one especially oddball webpage, VA Shiva Ayyadurai claims to have actually invented email in 1978. (http://www.inventorofemail.com). Mr. Ayyadurai mostly substantiates his claim by playing games with the definition of what email is, basically arguing that email didn’t exist until his particular program was written, and that nothing beforehand actually amounted to what he defines as being email. I won’t play those games with you here. […]

And, the #1 ESS ADF was in full production service February 3, 1969…almost five years before Ray Tomlinson sent the first email message and well before ARPANet even existed. To clarify, that was full commercial service…not a research laboratory.

When the #1 ESS ADF system was cut into service in 1969, it was of a truly massive scale for the time. 1,250 terminals located in 720 locations across the country were connected. These were used by Western Electric and AT&T Long Lines to send administrative messages, traffic orders, commercial service orders, payroll, plant service results, and budgeting reports. There was no other system, including universities, with such widespread use.

Full Story: Cloudave: The Origin of Email

The system is described in the Bell System Technical Journal in 1970, and is also mentioned by Jim Haynes in an essay on Teletype Corporation.

A Web Comic About Steve Jobs And Steve Wozniak As Young Hippies

Patrick Farley, the artist behind the pioneering web comic E-Sheep, has a series that started today. Steve and Steve follows the adventures of Apple Computer founders Steve Jobs and Steve Wozniak as young, acid tripping hippies in the 70s. The ending of the prologue makes me think this may be an alternate history comic. It also displays the fascination with early hominids found in Farley’s last comic the First Word.